Topographic gradients define the projection patterns of the claustrum core and shell in mice.

ABSTRACT: The claustrum is densely connected to the cortex and participates in brain functions such as attention and sleep. Although some studies have reported the widely divergent organization of claustrum projections, others describe parallel claustrocortical connections to different cortical regions. Therefore, the details underlying how claustrum neurons broadcast information to cortical networks remain incompletely understood. Using multicolor retrograde tracing we determined the density, topography, and co-projection pattern of 14 claustrocortical pathways, in mice. We spatially registered these pathways to a common coordinate space and found that the claustrocortical system is topographically organized as a series of overlapping spatial modules, continuously distributed across the dorsoventra

SUBMITTER: Marriott BA 

PROVIDER: S-EPMC8048916 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature