Platelet Glycoprotein Ib α-Chain as a Putative Therapeutic Target for Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.

ABSTRACT:

Objective

To ascertain the role of platelet glycoprotein Ib α-chain (GPIbα) plasma protein levels in cardiovascular, autoimmune, and autoinflammatory diseases and whether its effects are mediated by platelet count.

Methods

We performed a two-sample Mendelian randomization (MR) study, using both a cis-acting protein quantitative trait locus (cis-pQTL) and trans-pQTL near the GP1BA and BRAP genes as instruments. To assess if platelet count mediated the effect, we then performed a two-step MR study. Putative associations (GPIbα/platelet count/disease) detected by MR analyses were subsequently assessed using multiple-trait colocalization analyses.

Results

After correction for multiple testing (Bonferroni-corrected threshold P ≤ 2 × 10^-3 ), GPIbα, instrumented b

SUBMITTER: Luo S 

PROVIDER: S-EPMC8048917 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature