Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus.

ABSTRACT:

Key points

Ventrolateral thalamus (VL) integrates information from cerebellar nuclei and motor cortical layer VI. Inputs from the cerebellar nuclei evoke large-amplitude responses that depress upon repetitive stimulation while layer VI inputs from motor cortex induce small-amplitude facilitating responses. We report that the spiking of VL neurons can be determined by the thalamic membrane potential, the frequency of cerebellar inputs and the duration of pauses after cerebellar high frequency stimulation. Inputs from motor cortical layer VI shift the VL membrane potential and modulate the VL spike output in response to cerebellar stimulation.  These results help us to decipher how the cerebellar output is integrated in VL and modulated by motor cortical input.

Abstract

Orches

SUBMITTER: Schafer CB 

PROVIDER: S-EPMC8048920 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature