Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community-based cohort study.

ABSTRACT:

Introduction

We investigated how components of immunity relate to biomarkers of Alzheimer's disease (AD) in plasma and explored the influence of AD genetic risk factors in the population-based Rotterdam Study.

Methods

In 7397 persons, we calculated the granulocyte-to-lymphocyte ratio (GLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In 3615 of these persons, plasma amyloid-beta (Aβ)42 and Aβ40 were measured. Next, we constructed an overall genetic risk score (GRS) based on genome-wide significant variants, both including and excluding APOE ε4.

Results

All innate immunity phenotypes were related to higher Aβ, most strongly with a doubling in GLR leading to a 1.9% higher Aβ42 (95% confidence interval [95% CI] 0.4 to 3.3%) and 3.2%

SUBMITTER: Fani L 

PROVIDER: S-EPMC8048997 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature