Ontology highlight
ABSTRACT:
SUBMITTER: Hatamie A
PROVIDER: S-EPMC8049002 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hatamie Amir A Ren Lin L Dou Haiqiang H Gandasi Nikhil R NR Rorsman Patrik P Ewing Andrew A
Angewandte Chemie (International ed. in English) 20210226 14
Recent work has shown that chemical release during the fundamental cellular process of exocytosis in model cell lines is not all-or-none. We tested this theory for vesicular release from single pancreatic beta cells. The vesicles in these cells release insulin, but also serotonin, which is detectible with amperometric methods. Traditionally, it is assumed that exocytosis in beta cells is all-or-none. Here, we use a multidisciplinary approach involving nanoscale amperometric chemical methods to e ...[more]