Treatment-resistant major depressive disorder: Canadian expert consensus on definition and assessment.

ABSTRACT:

Background

Treatment-resistant depression (TRD) is a debilitating chronic mental illness that confers increased morbidity and mortality, decreases the quality of life, impairs occupational, social, and offspring development, and translates into increased costs on the healthcare system. The goal of this study is to reach an agreement on the concept, definition, staging model, and assessment of TRD.

Methods

This study involved a review of the literature and a modified Delphi process for consensus agreement. The Appraisal of Guidelines for Research & Evaluation II guidelines were followed for the literature appraisal. Literature was assessed for quality and strength of evidence using the grading, assessment, development, and evaluations system. Canadian national experts in depr

SUBMITTER: Rybak YE 

PROVIDER: S-EPMC8049072 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature