High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons.

ABSTRACT: High dietary salt increases arterial pressure partly through activation of magnocellular neurosecretory cells (MNC^VP) that secrete the antidiuretic and vasoconstrictor hormone vasopressin (VP) into the circulation. Here, we show that the intrinsic and synaptic excitation of MNC^VP caused by hypertonicity are differentially potentiated in two models of salt-dependent hypertension in rats. One model combined salty chow with a chronic subpressor dose of angiotensin II (AngII-salt), the other involved replacing drinking water with 2% NaCl (salt loading, SL). In both models, we observed a significant increase in the quantal amplitude of EPSCs on MNC^VP. However, model-specific changes were also observed. AngII-salt increased the probability of glutamate release by

SUBMITTER: Levi DI 

PROVIDER: S-EPMC8049100 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature