Simplified Quantification of ¹¹C-UCB-J PET Evaluated in a Large Human Cohort.

ABSTRACT: ¹¹C-UCB-J ((R)-1-((3-(¹¹C-methyl-¹¹C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BP _ND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BP _ND Simulations were performed to assess the time dependency of SUVR-1.

SUBMITTER: Naganawa M 

PROVIDER: S-EPMC8049341 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature