Voxelwise and Patientwise Correlation of ¹⁸F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naive Diffuse Gliomas with Different Molecular Subtypes.

ABSTRACT: Our purpose was to identify correlations between ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes and to evaluate their prognostic values. Methods: Sixty-eight treatment-naïve glioma patients who underwent ¹⁸F-FDOPA PET and physiologic MRI were retrospectively selected (36 with isocitrate dehydrogenase wild-type [IDH_wt], 16 with mutant 1p/19q noncodeleted [IDH_m-noncodel], and 16 with mutant codeleted [IDH_m-codel]). Fluid-attenuated inversion recovery hyperintense areas were segmented and used as regions of interest. For voxelwise and patientwise analyses, Pearso

SUBMITTER: Tatekawa H 

PROVIDER: S-EPMC8049346 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature