Head-to-Head Evaluation of ¹⁸F-FES and ¹⁸F-FDG PET/CT in Metastatic Invasive Lobular Breast Cancer.

ABSTRACT: Invasive lobular carcinoma (ILC) demonstrates lower conspicuity on ¹⁸F-FDG PET than the more common invasive ductal carcinoma. Other molecular imaging methods may be needed for evaluation of this malignancy. As ILC is nearly always (95%) estrogen receptor (ER)-positive, ER-targeting PET tracers such as 16α-¹⁸F-fluoroestradiol (¹⁸F-FES) may have value. We reviewed prospective trials at Memorial Sloan Kettering Cancer Center using ¹⁸F-FES PET/CT to evaluate metastatic ILC patients with synchronous ¹⁸F-FDG and ¹⁸F-FES PET/CT imaging, which allowed a head-to-head comparison of these 2 PET tracers. Methods: Six prospective clinical trials using ¹⁸F-FES PET/CT in patients with metastatic breast cancer were perfor

SUBMITTER: Ulaner GA 

PROVIDER: S-EPMC8049349 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature