PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is the most common noninfectious pulmonary disease among people living with HIV, independent of smoking. However, the cause for this enhanced susceptibility remains unclear, and the effects of HIV on pulmonary perfusion and ventilation are unknown. Methods: We used PET/CT in 46 smokers and nonsmokers, 23 of whom had documented HIV infection. Emphysema was assessed by CT and perfusion by ¹³N (¹³NN) PET scans. After removal of image noise, vertical and axial gradients in perfusion were calculated. We tested for differences in the total spatial heterogeneity of perfusion (CV² _Qtotal) and its components (CV² _Qtotal = CV² _Qvgrad [vertical gradient] + CV

SUBMITTER: Kohli P 

PROVIDER: S-EPMC8049351 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature