γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs.

ABSTRACT: With the successful development and increased use of targeted radionuclide therapy for treating cancer comes the increased risk of radiation injury to bone marrow-both direct suppression and stochastic effects, leading to neoplasia. Herein, we report a novel radioprotector drug, a liposomal formulation of γ-tocotrienol (GT3), or GT3-Nano for short, to mitigate bone marrow radiation damage during targeted radionuclide therapy. Methods: GT3 was loaded into liposomes using passive loading. ⁶⁴Cu-GT3-Nano and ³H-GT3-Nano were synthesized to study the in vivo biodistribution profile of the liposome and GT3 individually. The radioprotection efficacy of GT3-Nano was assessed after acute ¹³⁷Cs whole-body irradiation at a sublethal (4 Gy), a lethal (9 Gy), or

SUBMITTER: Lee SG 

PROVIDER: S-EPMC8049360 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature