Treatment Monitoring of Immunotherapy and Targeted Therapy Using ¹⁸F-FET PET in Patients with Melanoma and Lung Cancer Brain Metastases: Initial Experiences.

ABSTRACT: We investigated the value of O-(2-¹⁸F-fluoroethyl)-l-tyrosine (¹⁸F-FET) PET for treatment monitoring of immune checkpoint inhibition (ICI) or targeted therapy (TT) alone or in combination with radiotherapy in patients with brain metastasis (BM) since contrast-enhanced MRI often remains inconclusive. Methods: We retrospectively identified 40 patients with 107 BMs secondary to melanoma (n = 29 with 75 BMs) or non-small cell lung cancer (n = 11 with 32 BMs) treated with ICI or TT who had ¹⁸F-FET PET (n = 60 scans) for treatment monitoring from 2015 to 2019. Most patients (n = 37; 92.5%) had radiotherapy during the course of the disease. In 27 patients, ¹⁸F-FET PET was used to differentiate treatment-related

SUBMITTER: Galldiks N 

PROVIDER: S-EPMC8049362 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature