Dataset Information

First-in-Humans Study of ⁶⁸Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.

ABSTRACT: Sialic acid-binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A ⁶⁸Ga-labeled peptide of Siglec-9, ⁶⁸Ga-DOTA-Siglec-9, holds promise as a novel PET tracer for imaging of inflammation. This first-in-humans study investigated the safety, tolerability, biodistribution, and radiation dosimetry of this radiopharmaceutical. Methods: Six healthy men underwent dynamic whole-body PET/CT. Serial venous blood samples were drawn from 1 to 240 min after intravenous injection of 162 ± 4 MBq of ⁶⁸Ga-DOTA-Siglec-9. In addition to γ-counting, the plasma samples were analyzed by high-performance liquid chromatography to detect intact tracer and radioactive metabolites. Radiation doses were calculated using the OLINDA/EXM softwar

SUBMITTER: Viitanen R

PROVIDER: S-EPMC8049366 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

First-in-Humans Study of ⁶⁸Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.

OmicsDI is part of the ELIXIR infrastructure

Tweets

First-in-Humans Study of ⁶⁸Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.