Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.

ABSTRACT: Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes, considered indistinguishable from bovine DD species, and a bovine gastrointestinal (GI) treponeme isolate. Key genomic differences between bovine and human treponemes implicate microbial mechanisms that enhance knowledge of how DD, a severe disease of ruminants, has emerged into a prolific, worldwide disease. Bovine DD treponemes have additional oxidative stress genes compared to nearest human-isolated relatives, suggesting better oxidative stress tolerance, and potentially explaining how bovine strains can colonize skin surfaces. Comparison of both bovine DD and GI treponemes as well as bovine pathogenic and human non-pathogen

SUBMITTER: Staton GJ 

PROVIDER: S-EPMC8049484 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature