RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry.

ABSTRACT:

Objectives

Despite disparities in lung cancer incidence and mortality, the molecular landscape of lung cancer in patients of African ancestry remains underexplored, and race-related differences in RNA splicing remain unexplored.

Materials and methods

We identified differentially spliced genes (DSGs) and differentially expressed genes (DEGs) in biobanked lung squamous cell carcinoma (LUSC) between patients of West African and European ancestry, using ancestral genotyping and Affymetrix Clariom D array. DSGs and DEGs were validated independently using the National Cancer Institute Genomic Data Commons. Associated biological processes, overlapping canonical pathways, enriched gene sets, and cancer relevance were identified using Gene Ontology Consortium, Ingenuity Pathway Analy

SUBMITTER: Deveaux AE 

PROVIDER: S-EPMC8049647 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature