Ontology highlight
ABSTRACT:
SUBMITTER: Mast AE
PROVIDER: S-EPMC8049742 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
eLife 20210308
Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profiles of bronchoalveolar lavage fluid (BALF) samples to identify molecular mechanisms underlying these coagulopathies. mRNA levels for regulators of the kallikrein-kinin (C1-inhibitor), coagulation (thrombomodulin, endothelial protein C receptor), and ...[more]