Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.

ABSTRACT:

Abstract

Sex differences in the quality and prevalence of chronic pain are manifold, with women generally presenting higher incidence and severity. Uncovering chronic pain-related sex differences inform neural mechanisms and may lead to novel treatment routes. In a multicenter morphological study (total n = 374), we investigated whether the shape of subcortical regions would reflect sex differences in back pain. Given the hormone-dependent functions of the hippocampus, and its role in the transition to chronic pain, this region constituted our primary candidate. We found that the anterior part of the left hippocampus (alHP) presented outer deformation in women with chronic back pain (CBP), identified in CBP in the United States (n = 77 women vs n = 78 men) and validated in a Chines

SUBMITTER: Reckziegel D 

PROVIDER: S-EPMC8049947 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature