High-Sensitivity Cardiac Troponin I for Risk Stratification in Older Adults.

ABSTRACT:

Background/objectives

Traditional cardiovascular risk factors are less predictive in older age. High-sensitivity cardiac troponin I (hs-cTnI) is a marker of subclinical cardiomyocyte damage associated with cardiovascular risk in middle-aged adults. We hypothesized hs-cTnI would be indicative of mortality and cardiovascular risk beyond traditional cardiovascular risk factors in older adults and may be more discriminatory compared to hs-troponin T (hs-cTnT).

Design

Prospective cohort study.

Setting

Population-based Atherosclerosis Risk in Communities (ARIC) Study.

Participants

We included 5,876 ARIC participants at Visit 5 (2011-2013).

Outcomes and measures

We used Cox regression for the association of hs-cTnI categories (women: <4, 4-<10, ≥10 ng/ml; men:

SUBMITTER: Tang O 

PROVIDER: S-EPMC8049956 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature