Pharmacogenetics factors influencing smoking cessation success; the importance of nicotine metabolism.

ABSTRACT: Introduction: Smoking remains a worldwide epidemic, and despite an increase in public acceptance of the harms of tobacco use, it remains the leading cause of preventable death. It is estimated that up to 70% of all smokers express a desire to quit, but only 3-5% of them are successful.Areas covered: The goal of this review was to evaluate the current status of smoking cessation treatments and the feasibility of implementing personalized-medicine approaches to these pharmacotherapies. We evaluated the genetics associated with higher levels of nicotine addiction and follow with an analysis of the genetic variants that affect the nicotine metabolic ratio (NMR) and the FDA approved treatments for smoking cessation. We also highlighted the gaps in the process of translating curren

SUBMITTER: Perez-Paramo YX 

PROVIDER: S-EPMC8049967 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature