Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return?

ABSTRACT:

Objectives

To investigate the rate and patterns of accumulation of frailty manifestations in relationship to all-cause mortality and whether there is a point in the progression of frailty beyond which the process becomes irreversible and death becomes imminent (a.k.a. point of no return).

Design

Longitudinal observational study.

Setting

Community or a non-nursing home residential care setting.

Participants

Two thousand five hundred and fifty seven robust older adults identified at baseline in 2011 with follow-up for all-cause mortality between 2011 and 2018.

Measurements

Frailty was measured by the physical frailty phenotype. Cox models were used to study the relationships of the number of frailty criteria (0-5) at each point in time and its accumulation

SUBMITTER: Xue QL 

PROVIDER: S-EPMC8049969 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature