Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment.

ABSTRACT: Vascular cognitive impairment (VCI) is a term that encompasses a continuum of cognitive disorders with cerebrovascular pathology contribution, ranging from mild cognitive impairment to vascular dementia (VaD). VCI and VaD, thus, represent an interesting intersection between cardiovascular disease and neurodegenerative disorders such as Alzheimer's disease (AD) and a rising area of research in recent years. Although VCI and VaD research has identified various causes and explanations for disease development, many aspects remain unclear, particularly sex differences in VCI (e.g., epidemiology), unlike those available for cardiovascular disease and AD. Despite limited information in the literature, several studies have observed an association of estrogen receptor (ER) polymorphisms and VaD. If

SUBMITTER: Nguyen DH 

PROVIDER: S-EPMC8050128 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature