Comparative analysis of histone H3K4me3 modifications between blastocysts and somatic tissues in cattle.

ABSTRACT: Epigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequences throughout life. This concept constitutes the "Developmental Origins of Health and Disease" (DOHaD) hypothesis and encompasses the possibility of controlling livestock health and diseases by epigenetic regulation during early development. As a preliminary step for examining changes of epigenetic modifications in early embryos and their long-lasting effects in fully differentiated somatic tissues, we aimed to obtain high-throughput genome-wide histone H3 lysine 4 trimethylation (H3K4me3) profiles of bovine blastocysts and to compare these data with those from adult somatic tissues in order to extract common and typical features between thes

SUBMITTER: Ishibashi M 

PROVIDER: S-EPMC8050253 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature