Neuroradiologic correlates of cognitive impairment in adult Moyamoya disease.

ABSTRACT:

Background and purpose

MMD has been shown to result in impairment of executive functioning in adults. The purpose of this study was to correlate presurgical neuropsychological assessments with the severity of primary MMD as measured by CBF and CVR and with secondary damage from MMD as estimated by cortical stroke and WMD.

Materials and methods

A retrospective analysis of 31 adult patients with MMD was performed. Xe-CT was used to obtain CBF and CVR, and MRI was reviewed to grade cortical stroke and WMD. Two tests of executive functioning (FAS and TMT-B) were correlated with imaging findings. A multiple regression analysis was performed.

Results

There was a significant overall positive relationship between mean CBF and FAS (P = .038) and TMT-B scores (P = .014). A sign

SUBMITTER: Mogensen MA 

PROVIDER: S-EPMC8050434 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature