Quantitative fiber tracking in the corpus callosum and internal capsule reveals microstructural abnormalities in preterm infants at term-equivalent age.

ABSTRACT:

Background and purpose

Signal-intensity abnormalities in the PLIC and thinning of the CC are often seen in preterm infants and associated with poor outcome. DTI is able to detect subtle abnormalities. We used FT to select bundles of interest (CC and PLIC) to acquire additional information on the WMI.

Materials and methods

One hundred twenty preterm infants born at <31 weeks' gestation with 3T DTI at TEA entered this prospective study. Quantitative information (ie, volume, length, anisotropy, and MD) was obtained from fiber bundles passing through the PLIC and CC. A general linear model was used to assess the effects of factor (sex) and variables (GA, BW, HC, PMA, and WMI) on FT-segmented parameters.

Results

Seventy-two CC and 85 PLIC fiber bundles were assessed. For t

SUBMITTER: van Pul C 

PROVIDER: S-EPMC8050470 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature