Establishment and validation of a prognostic signature for lung adenocarcinoma based on metabolism-related genes.

ABSTRACT:

Background

Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metabolism-related genes (MRGs).

Methods

The gene sequencing data of LUAD samples with clinical information and the metabolism-related gene set were obtained from The Cancer Genome Atlas (TCGA) and Molecular Signatures Database (MSigDB), respectively. The differentially expressed MRGs were identified by Wilcoxon rank sum test. Then, univariate cox regression analysis was performed to identify MRGs that related to overall survival (OS). A prognostic signature was developed by multivariate Cox regression analysis. Furthermore, the signature was validated in the GSE3121

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8050921 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature