<i>RAB11FIP5</i>-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.

ABSTRACT: Rab11 recycling endosomes are involved in immunological synaptic functions, but the roles of Rab11 family-interacting protein 5 (Rab11Fip5), one of the Rab11 effectors, in the immune system remain obscure. Our previous study demonstrated that RAB11FIP5 transcripts are significantly elevated in PBMCs from HIV-1-infected individuals, making broadly HIV-1-neutralizing Abs compared with those without broadly neutralizing Abs; however, the role of Rab11FiP5 in immune functions remains unclear. In this study, a RAB11FIP5 gene knockout (RAB11FIP5 ^-/-) mouse model was employed to study the role of Rab11Fip5 in immune responses. RAB11FIP5 ^-/- mice exhibited no perturbation in lymphoid tissue cell subsets, and Rab11Fip5 was not required for serum Ab

SUBMITTER: Li D 

PROVIDER: S-EPMC8050958 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature