Pharmacogenomics of oxycodone: a narrative literature review.
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ABSTRACT:
SUBMITTER: Umukoro NN
PROVIDER: S-EPMC8050982 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Pharmacogenomics of oxycodone: a narrative literature review.
Umukoro Nelly N NN Aruldhas Blessed W BW Rossos Ryan R Pawale Dhanashri D Renschler Janelle S JS Sadhasivam Senthilkumar S
Pharmacogenomics 20210317 5
Oxycodone is a semisynthetic μ- and κ-opioid receptor with agonist with a broad scope of use including postoperative analgesia as well as control of neuropathic and cancer pain. Advantages over other opioids include prolonged duration of action, greater potency than morphine and lack of histamine release or ceiling effect. Individual responses to oxycodone can vary due to genetic differences. This review article aims to summarize the oxycodone literature and provide context on its pharmacogenomi ...[more]
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