Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements.

ABSTRACT:

Background

Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health.

Method/design

Men and women (calculated sample size = 60), aged 18-45 years, with body mass index of 27-35 kg/m² will be included in a double-blind 8-week dietary intervention study. The participants will be randomized in a 1:1 manner to a diet with either low or high SAA. Both groups will receive an equal base diet consisting of low-SAA plant-based whole foods and an amino acid supplement free o

SUBMITTER: Stolt E 

PROVIDER: S-EPMC8051033 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature