Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans.

ABSTRACT:

Background

Apicomplexa is a diverse phylum comprising unicellular endobiotic animal parasites and contains some of the most well-studied microbial eukaryotes including the devastating human pathogens Plasmodium falciparum and Cryptosporidium hominis. In contrast, data on the invertebrate-infecting gregarines remains sparse and their evolutionary relationship to other apicomplexans remains obscure. Most apicomplexans retain a highly modified plastid, while their mitochondria remain metabolically conserved. Cryptosporidium spp. inhabit an anaerobic host-gut environment and represent the known exception, having completely lost their plastid while retaining an extremely reduced mitochondrion that has lost its genome. Recent advances in single-cell sequencing have enabled the first broa

SUBMITTER: Salomaki ED 

PROVIDER: S-EPMC8051059 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature