Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients.

ABSTRACT:

Background

Exosomal circular RNAs (circRNAs) are emerging as important regulators of physiological development and disease pathogenesis. However, the roles of exosomal circRNAs from umbilical cord blood in preeclampsia (PE) occurrence remains poorly understood.

Methods

We used microarray technology to establish the differential circRNA expression profiles in umbilical cord blood exosomes from PE patients compared with normal controls. Bioinformatics analysis was conducted to further predict the potential effects of the differentially expressed circRNAs and their interactions with miRNAs.

Results

According to the microarray data, we identified 143 significantly up-regulated circRNAs and 161 significantly down-regulated circRNAs in umbilical cord blood exosomes of PE pa

SUBMITTER: Cao M 

PROVIDER: S-EPMC8051099 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature