Multi-omic profiling of pituitary thyrotropic cells and progenitors.

ABSTRACT:

Background

The pituitary gland is a neuroendocrine organ containing diverse cell types specialized in secreting hormones that regulate physiology. Pituitary thyrotropes produce thyroid-stimulating hormone (TSH), a critical factor for growth and maintenance of metabolism. The transcription factors POU1F1 and GATA2 have been implicated in thyrotrope fate, but the transcriptomic and epigenomic landscapes of these neuroendocrine cells have not been characterized. The goal of this work was to discover transcriptional regulatory elements that drive thyrotrope fate.

Results

We identified the transcription factors and epigenomic changes in chromatin that are associated with differentiation of POU1F1-expressing progenitors into thyrotropes using cell lines that represent an undiffere

SUBMITTER: Daly AZ 

PROVIDER: S-EPMC8051135 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature