ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways.

ABSTRACT: Cells losing the ability to self-regulate in response to damage are a hallmark of cancer. When a cell encounters damage, regulatory pathways estimate the severity of damage and promote repair, cell cycle arrest, or apoptosis. This decision-making process would be remarkable if it were based on the total amount of damage in the cell, but because damage detection pathways vary in the rate and intensity with which they promote pro-apoptotic factors, the cell's real challenge is to reconcile dissimilar signals. Crosstalk between repair pathways, crosstalk between pro-apoptotic signaling kinases, and signals induced by damage by-products complicate the process further. The cell's response to [Formula: see text] and UV radiation neatly illustrates this concept. While these forms of radiation pro

SUBMITTER: Fedak EA 

PROVIDER: S-EPMC8051223 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature