Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation.

ABSTRACT: In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A^∗02:01 (29.5%), B^∗51:01 (10.5%), C^∗04:01 (15.8%), and DRB1^∗16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A^∗01:01~C^∗07:01~B^∗08:01~DRB1^∗03:01 (4.7%), HLA-A^∗03:01~C^∗07:02~B^∗07:02~DRB1^∗15:01 (1.7%), and HLA-A^∗02:01~C^∗07:01~B^∗18:01~DRB1^∗</

SUBMITTER: Grubic Z 

PROVIDER: S-EPMC8051524 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature