Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival.

ABSTRACT:

Purpose

Compared with their European American (EA) counterparts, African American (AA) women are more likely to die from breast cancer in the United States. This disparity is greatest in hormone receptor-positive subtypes. Here we uncover biological factors underlying this disparity by comparing functional expression and prognostic significance of master transcriptional regulators of luminal differentiation.

Experimental design

Data and biospecimens from 262 AA and 293 EA patients diagnosed with breast cancer from 2001 to 2010 at a major medical center were analyzed by IHC for functional biomarkers of luminal differentiation, including estrogen receptor (ESR1) and its pioneer factors, FOXA1 and GATA3. Integrated comparison of protein levels with network-

SUBMITTER: Byun JS 

PROVIDER: S-EPMC8051554 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature