Meiotic sister chromatid exchanges are rare in C. elegans.

ABSTRACT: Sexual reproduction shuffles the parental genomes to generate new genetic combinations. To achieve that, the genome is subjected to numerous double-strand breaks, the repair of which involves two crucial decisions: repair pathway and repair template.¹ Use of crossover pathways with the homologous chromosome as template exchanges genetic information and directs chromosome segregation. Crossover repair, however, can compromise the integrity of the repair template and is therefore tightly regulated. The extent to which crossover pathways are used during sister-directed repair is unclear because the identical sister chromatids are difficult to distinguish. Nonetheless, indirect assays have led to the suggestion that inter-sister crossovers, or sister chromatid exchanges (SCEs), are

SUBMITTER: Almanzar DE 

PROVIDER: S-EPMC8051885 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature