Evaluation of association between methylenetetrahydrofolate reductase and azoospermia: A meta-analysis.

ABSTRACT:

Background

Infertility affects childbearing age couples all over the world. One of the important reasons for infertility is genetic factors. Our study evaluated the association between methylenetetrahydrofolate reductase (MTHFR) and azoospermia.

Methods

Multiple databases like MEDLINE, EMBASE, Cochrane library, and China journal full-text database were used to search for relevant studies, and full-text articles involved in the evaluation of MTHFR and azoospermia. The results were evaluated using STATA 12.0. Heterogeneity analysis, sensitivity analysis, and bias analysis were also performed on the data.

Results

Thirteen related studies eventually met the inclusion criteria. Significant association between C677T polymorphism and azoospermia (relative risk [RR] = 0.94 [0

SUBMITTER: Tan GX 

PROVIDER: S-EPMC8051989 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature