MiR-218 in Adolescence Predicts and Mediates Vulnerability to Stress.

ABSTRACT:

Background

Adolescence is a period of increased vulnerability to psychiatric disorders, including depression. Discovering novel biomarkers to identify individuals who are at high risk is very much needed. Our previous work shows that the microRNA miR-218 mediates susceptibility to stress and depression in adulthood by targeting the netrin-1 guidance cue receptor gene Dcc in the medial prefrontal cortex (mPFC).

Methods

Here, we investigated whether miR-218 regulates Dcc expression in adolescence and could serve as an early predictor of lifetime stress vulnerability in male mice.

Results

miR-218 expression in the mPFC increases from early adolescence to adulthood and correlates negatively with Dcc levels. In blood, postnatal miR-218 expression parallels changes occurrin

SUBMITTER: Torres-Berrio A 

PROVIDER: S-EPMC8052258 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature