The Impact of Liver Transplantation on Hepatocellular Carcinoma Mortality in the United States.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) carries a poor prognosis. Liver transplantation (LT) is potentially curative for localized HCC. We evaluated the impact of LT on U.S. general population HCC-specific mortality rates.

Methods

The Transplant Cancer Match Study links the U.S. transplant registry with 17 cancer registries. We calculated age-standardized incidence (1987-2017) and incidence-based mortality (IBM) rates (1991-2017) for adult HCCs. We partitioned population-level IBM rates by cancer stage and calculated counterfactual IBM rates assuming transplanted cases had not received a transplant.

Results

Among 129,487 HCC cases, 45.9% had localized cancer. HCC incidence increased on average 4.0% annually [95% confidence interval (CI) = 3.6-4.5]. IBM also increase

SUBMITTER: Mahale P 

PROVIDER: S-EPMC8052263 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature