Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis.

ABSTRACT: Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of five Tabebuia species was analyzed. The highest activity was observed for T. rosea (Bertol.) DC. stem extract against HepG2 cell line (IC₅₀ 4.7 µg/mL), T. pallida L. stem extract against MCF-7 cell line (IC₅₀ 6.3 µg/mL), and T. pulcherrima stem extract against CACO2 cell line (IC₅₀ 2.6 µg/mL). Metabolic profiling of the ten extracts using liquid chromatography-high-resolution mass spectrometry for dereplication purposes led to annotation of forty compounds belonging to different chemical classes. Among the annotated compounds, irridoids represent the major

SUBMITTER: El-Hawary SS 

PROVIDER: S-EPMC8052319 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature