Ontology highlight
ABSTRACT:
SUBMITTER: Zhu G
PROVIDER: S-EPMC8052337 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Zhu Guoqing G Murshed Abduh A Li Haojie H Ma Ji J Zhen Ni N Ding Miao M Zhu Jiabei J Mao Siwei S Tang Xiaochen X Liu Li L Sun Fenyong F Jin Lei L Pan Qiuhui Q
Cell death discovery 20210416 1
Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation of lipid hydroperoxides to lethal levels. YAP has been reported to play a pivotal role in controlling ferroptotic death, and the expression of YAP is enhanced and stabilized by O-GlcNAcylation. However, whether O-GlcNAcylation can increase the sensitivity of hepatocellular carcinoma (HCC) cells to ferroptosis remains unknown. In the present study, we found that O-GlcNAcylation increased the sensitivity of ...[more]