Phenotypic discordance between primary and metastatic breast cancer in the large-scale real-life multicenter French ESME cohort.

ABSTRACT: Expression of hormone receptor (HR) for estrogens (ER) and progesterone (PR) and HER2 remains the cornerstone to define the therapeutic strategy for breast cancer patients. We aimed to compare phenotypic profiles between matched primary and metastatic breast cancer (MBC) in the ESME database, a National real-life multicenter cohort of MBC patients. Patients with results available on both primary tumour and metastatic disease within 6 months of MBC diagnosis and before any tumour progression were eligible for the main analysis. Among the 16,703 patients included in the database, 1677 (10.0%) had available biopsy results at MBC diagnosis and on matched primary tumour. The change rate of either HR or HER2 was 27.0%. Global HR status changed (from positive = either ER or PR positive, to negati

SUBMITTER: Grinda T 

PROVIDER: S-EPMC8052407 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature