The natural history of 21-hydroxylase autoantibodies in autoimmune Addison's disease.

ABSTRACT:

Background

The most common cause of primary adrenal failure (Addison's disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection of 21OH-autoantibodies is currently used for aetiological diagnosis, but how levels of 21OH-autoantibodies vary over time is not known.

Setting

Samples from the national Norwegian Addison's Registry and Biobank established in 1996 (n = 711). Multi-parameter modelling of the course of 21OH-autoantibody indices over time.

Results

21OH-autoantibody positivity is remarkably stable, and >90% of the patients are still positive 30 years after diagnosis. Even though the antibody levels decline with disease duration, it is only rarely that this downturn rea

SUBMITTER: Wolff AB 

PROVIDER: S-EPMC8052519 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature