Lower pattern recognition memory scores in anorexia nervosa.

ABSTRACT:

Background

There is extensive evidence for volumetric reductions in the hippocampus in patients with anorexia nervosa (AN), however the impact on function is unclear. Pattern separation and recognition are hippocampus-dependent forms of learning thought to underlie stimulus discrimination.

Methods

The present study used the Mnemonic Similarity Task to investigate pattern separation and recognition for the first time in patients with AN (N = 46) and healthy controls (N = 56). An Analysis of Covariance examined between-group differences, controlling for age, antidepressant use and method of task delivery (remote vs. in person).

Results

When controlling for covariates, pattern recognition memory scores were lower in the AN group with a medium effect size (d = 0.51). In c

SUBMITTER: Keeler J 

PROVIDER: S-EPMC8052530 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature