Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO.

ABSTRACT:

Objective

ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO.

Methods

A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0-100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index.

Results

ROC analyses provided group-MIC estimates of 6.3-14.3 (score range 0-100). Evaluation of area

SUBMITTER: Nordqvist SF 

PROVIDER: S-EPMC8052573 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature