Changes in brain and behavior during food-based decision-making following treatment of anorexia nervosa.

ABSTRACT:

Background

Anorexia nervosa is a severe illness with a high mortality rate, driven in large part by severe and persistent restriction of food intake. A critical challenge is to identify brain mechanisms associated with maladaptive eating behavior and whether they change with treatment. This study tested whether food choice-related caudate activation in anorexia nervosa changes with treatment.

Methods

Healthy women (n = 29) and women hospitalized with anorexia nervosa (n = 24), ages 18 to 40 years, completed a Food Choice Task during fMRI scanning at two timepoints. Among patients, procedures occurred upon hospital admission (Time 1) and again after patients had gained to normal weight (Time 2). Healthy controls were tested twice at an interval group-matched to patients. Choi

SUBMITTER: Foerde K 

PROVIDER: S-EPMC8052661 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature