Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer.

ABSTRACT:

Background

Currently, over half of breast cancer cases are unrelated to known risk factors, highlighting the importance of discovering other cancer-promoting factors. Since crosstalk between gut microbes and host immunity contributes to many diseases, we hypothesized that similar interactions could occur between the recently described breast microbiome and local immune responses to influence breast cancer pathogenesis.

Methods

Using 16S rRNA gene sequencing, we characterized the microbiome of human breast tissue in a total of 221 patients with breast cancer, 18 individuals predisposed to breast cancer, and 69 controls. We performed bioinformatic analyses using a DADA2-based pipeline and applied linear models with White's t or Kruskal-Wallis H-tests with Benjamini-Hochberg mu

SUBMITTER: Tzeng A 

PROVIDER: S-EPMC8052771 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature