The prognostic significance of survivin expression in patients with HNSCC: a systematic review and meta-analysis.

ABSTRACT:

Background

Survivin has been recently identified as a promising novel therapeutic target and prognostic marker in different types of cancer. Here we conducted a comprehensive meta-analysis to better clarify they the precise prognostic and diagnostic value of survivin in head and neck squamous cell carcinoma (HNSCC).

Methods

Database of PubMed (Medline), Embase, and Web of Science were systematically searched for related published literature up to September 2020. Pooled hazards ratios (HR) and related 95% confidence intervals (CI) were used to estimate the association of survivin expression and survival outcomes in HNSCC patients.

Results

Twenty eight studies with 4891 patients were finally included in this meta-analysis, the pooled analysis indicated that the survivin

SUBMITTER: Zhou LQ 

PROVIDER: S-EPMC8052826 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature