HLA-B*35:01 and Green Tea-Induced Liver Injury.

ABSTRACT:

Background and aims

Herbal supplements, and particularly multi-ingredient products, have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. The aim of this study was to better characterize the clinical features, outcomes, and pathogenesis of green tea-associated liver injury.

Approach and results

Among 1,414 patients enrolled in the U.S. Drug-Induced Liver Injury Network who underwent formal causality assessment, 40 cases (3%) were attributed to green tea, 202 to dietary supplements without green tea, and 1,142 to conventional drugs. The clinical features of green tea cases and representation of human leukocyte antigen (HLA) class I and II alleles in cases and contr

SUBMITTER: Hoofnagle JH 

PROVIDER: S-EPMC8052949 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature