Temporal inversion of the acid-base equilibrium in newborns: an observational study.

ABSTRACT:

Background

A considerable fraction of newborn infants experience hypoxia-ischaemia and metabolic acidosis at birth. However, little is known regarding the biological response of newborn infants to the pH drift from the physiological equilibrium. The aim of this study was to investigate the relationship between the pH drift at birth and postnatal acid-base regulation in newborn infants.

Methods

Clinical information of 200 spontaneously breathing newborn infants hospitalised at a neonatal intensive care centre were reviewed. Clinical variables associated with venous blood pH on days 5-7 were assessed.

Results

The higher blood pH on days 5-7 were explained by lower cord blood pH (-0.131, -0.210 to -0.052; regression coefficient, 95% confidence interval), greater gestatio

SUBMITTER: Mizutani Y 

PROVIDER: S-EPMC8052977 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature